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A new approach for the support of your patients in treating depression

deprexis® offers clinically-proven online cognitive behavioural therapy (CBT) in a 90-day program. How could deprexis® help your adult patients with depression?


deprexis® an evidence-based program

What is deprexis® ?

deprexis® is an interactive, evidence-based online program that offers CBT support to patients aged 18 and over who are suffering from unipolar depression or depressive disorders.

deprexis® is broad and integrative. It primarily consists of recognized treatment elements of CBT, but also includes aspects of other psychotherapeutic approaches, such as mindfulness, acceptance, and problem solving.

deprexis® has been rigorously evaluated in 12 randomized clinical trials.

Who developed deprexis® ?

deprexis® has been developed by a multidisciplinary team of clinical psychologists, physicians, software engineers, and graphic designers at Gaia AG, Hamburg, Germany, a company specialized in research and development in digital therapeutics. Servier has the exclusive rights for the promotion and distribution of deprexis® in certain countries including Singapore.

deprexis® an innovative approach

deprexis® includes 10 modules and 1 summary module, primarily based on Cognitive Behavorial Therapy (CBT).

deprexis® is tailored to each individual: users browse the program by choosing from predefined response options and the next content is tailored to suit the previously expressed needs and preferences (Meyer et al., 2009). The display order of the content may vary, as well as the detail, depending on the preferences of the user. Text sections are also added or omitted, depending on the user’s personal choice, and some dialogues are only shown to those who have similar interests.

deprexis® also includes audio recordings, downloadable worksheets and a range of exercises, including mental imagery and relaxation to engage the patient and enable them to put the CBT they have learned into practice.

Patients have the option to repeat deprexis® activites and exercises at a time that suits them during the 90-days. They can print the exercises and practice them afterwards.

deprexis® allows the patient to monitor the course of their symptoms over time using “Mood check” and the PHQ-9 and discuss it during the follow-up visits with the health care professional.

How can the patient obtain access to deprexis®?

the patient registers directly after receiving the access card by the health care professional
the patient is then able to start using deprexis® for 90 days
during this period the patient can print their results and share them with his/her health care professional

Clinical trials

deprexis® is a CE marked medical device registered with Health Science Authority, Singapore. Software, in order to qualify for the CE marking as a medical device, must comply with a set of specific regulations and laws (e.g. regulations on data security, technical functionality and management of adverse events ). The fact that a medical device has CE marking gives the health care professional the certainty that the program is safe and operative as intended, because manufacturers of medical devices are legally obliged to ensure that they meet these conditions.
deprexis® has been rigorously evaluated in 12 randomized clinical trials. In these trials, deprexis® was used alone (in addition to care as usual) or in combination with other methods of treating depression, such as antidepressants and / or psychotherapy. You can see the clinical studies below. (By Clicking on the study, you will be redirected to the publication.)


Effectiveness of a Novel Integrative Online Treatment for Depression (deprexis®): Randomized Controlled Trial. Meyer, B., et al. J Med Internet Res 2009, 11 (2): e15. Doi 10.2196 / jmtr.1151.

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Internet-Based Treatment of Depression: A Randomized Controlled Τrial Comparing Guided with Unguided Self-Help. Berger et al., Cognitive Behavior Therapy 2011, 40 (4): 251-266.

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A randomized controlled trial of internet-based therapy in depression. Moritz et al., Behavior Research and Therapy 2012, 50: 513-521.

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An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Fischer, A., et al. Lancet psychiatry. 2015; 2 (3): 217-223.

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Efficacy of a psychological online intervention for depression in people with epilepsy: A randomized controlled trial.
Schröder et al., Epilepsy 2014, 55 (12): 2069-2076.

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Effects of an Internet intervention (deprexis®) on severe depression symptoms: Randomized controlled trial.
Meyer, B., et al., Internet Interventions. 2015; 2 (1): 48-59.

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Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
Klein, JP, et al., Psychother Psychosome, 2016. 85 (4): 218-28.

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Effectiveness of an Internet Intervention (deprexis®) for Depression in a United States Adult Sample: A Parallel-Group Pragmatic Randomized Controlled Trial.
Beevers, C. G., et al., Online First Publication, February 23, 2017.

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Effectiveness of an individually-tailored computerised CBT programme (deprexis®) for depression: A meta-analysis.
Twomey C et al., Psychiatry Res 2017; 256: 371-377. doi: 10.1016 / j.psychres.2017.06.08 [Epub ahead of print].

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Online Self-Help as an Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach
Zwerenz R et al., Online Self-Help as to Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach. Psychotherapy and psychosomatics. 2017; 86: 341-50.

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Evaluating an e-mental health program (deprexis®) as an adjunctive treatment tool in psychotherapy for depression: Results of a pragmatic randomized controlled trial.
Berger T, Krieger T, Sude K, Meyer B, et al. Journal of Affective Disorders. 2018; 227: 455-62.

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Efficacy of Self-guided Internet-Based Cognitive Behavioral Therapy in the Treatment of Depressive Symptoms A Meta-analysis of Individual Participant Data.
Karyotaki E et al., Published online February 22, 2017 JAMA Psychiatry. doi:10.1001/jamapsychiatry.2017.0044.

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